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Techniques in Immunology
Cell communication: Gap junction
GAP junctions are macromolecular structures that form channels which connect adjacent cells allowing the passage of molecules up to 1 kDa in size between mammalian cells. Thus, ions, second messengers and other small molecules can be exchanged between cells.
Gap junction channels can be regulated by various agents, including calcium, intracellular tension, pH, adhesion proteins, extracellular matrix and hormones.